| Peritonitis
Zerbaxa vs Albuked 25%
Side-by-side clinical, coverage, and cost comparison for peritonitis.Deep comparison between: Zerbaxa vs Albuked with Prescriber.AI
AI compares prescribing info and payer-specific access barriers across 1,200+ formularies. Here's a preview of what prescribers are already asking.Safety signalsAlbuked has a higher rate of injection site reactions vs Zerbaxa based on FDA-approved prescribing information
Coverage gaps3 major payers require step therapy for Albuked but not Zerbaxa, including UnitedHealthcare
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Category
Zerbaxa
Albuked
At A Glance
IV infusion
Every 8 hours
Cephalosporin/beta-lactamase inhibitor
IV infusion
Plasma volume expander
Indications
- Peritonitis
- Urinary tract infection
- Pyelonephritis
- Hospital acquired pneumonia
- VABP
- Hypoproteinemia
- Respiratory Distress Syndrome, Adult
- Liver Failure, Acute
- Erythroblastosis, Fetal
- Peritonitis
- Pancreatitis
- Mediastinitis
- Cellulitis
- Nephrotic Syndrome
Dosing
Peritonitis 1.5 g IV every 8 hours over 1 hour for 4 to 14 days, used in conjunction with metronidazole 500 mg IV every 8 hours; pediatric patients: 30 mg/kg up to 1.5 g every 8 hours for 5 to 14 days.
Urinary tract infection, Pyelonephritis 1.5 g IV every 8 hours over 1 hour for 7 days; pediatric patients: 30 mg/kg up to 1.5 g every 8 hours for 7 to 14 days.
Hospital acquired pneumonia, VABP 3 g IV every 8 hours over 1 hour for 8 to 14 days in adult patients 18 years and older.
Hypovolemic Shock Volume administered and speed of infusion adapted to the response of the individual patient; IV infusion.
Burns Beyond 24 hours post-injury, maintain plasma albumin ~2.5 +/- 0.5 g per 100 mL with plasma oncotic pressure of 20 mm Hg; IV infusion.
Hypoproteinemia 50-75 g daily (adults), 25 g daily (children); rate not exceeding 2 mL/min; IV infusion.
Contraindications
- Known serious hypersensitivity to components of ZERBAXA (ceftolozane and tazobactam), piperacillin/tazobactam, or other members of the beta-lactam class
- History of congestive cardiac failure, renal insufficiency, or stabilized chronic anemia (risk of circulatory overload)
- History of allergic reaction to albumin
Adverse Reactions
Most common (>=5%) Nausea, diarrhea, headache, pyrexia
Serious Hypersensitivity reactions, Clostridioides difficile-associated diarrhea, intracranial hemorrhage, renal impairment/renal failure, hepatic transaminase increased
Allergic urticaria, chills, fever, changes in respiration, pulse, and blood pressure
From excessive administration high plasma protein levels
Pharmacology
Ceftolozane is a cephalosporin antibacterial that inhibits bacterial cell wall biosynthesis by binding to penicillin-binding proteins (PBPs); tazobactam is an irreversible beta-lactamase inhibitor that extends ceftolozane activity against beta-lactamase-producing organisms.
Albumin (Human) is a plasma protein that exerts oncotic (colloid osmotic) pressure, expanding plasma volume by drawing fluid from extravascular tissues; it also functions as a transport protein capable of binding substances such as bilirubin.
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Most Common Insurance
Anthem BCBS
Zerbaxa
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (6/12) · Qty limit (0/12)
Albuked
- Covered on 5 commercial plans
- PA (6/12) · Step Therapy (0/12) · Qty limit (0/12)
UnitedHealthcare
Zerbaxa
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Albuked
- Covered on 4 commercial plans
- PA (0/8) · Step Therapy (0/8) · Qty limit (0/8)
Humana
Zerbaxa
- Covered on 0 commercial plans
- PA (0/3) · Step Therapy (0/3) · Qty limit (0/3)
Albuked
- Covered on 0 commercial plans
- PA (1/3) · Step Therapy (0/3) · Qty limit (0/3)
Coverage data sourced from MMIT. Updated monthly.
Savings
No savings programs available for Zerbaxa.
No savings programs available for Albuked.
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ZerbaxaView full Zerbaxa profile
AlbukedView full Albuked profile
Clinical data sourced from FDA-approved labeling. Coverage data via MMIT. Updated monthly.